Sep 01, · Cancer Research Print ISSN: Journal of Cancer Research ISSN: American Journal of Cancer ISSN: Advertisement Cancer research encompasses a broad array of re-search and includes a diverse range of specific research topics. Within this report, cancer research is defined as research where the published results include ‘cancer’ or ‘oncology’ within the title, abstract, or list of keywords of the publications, as indexed in the Scopus database. This TOPIC: Research Paper on Cancer Cell Biology Assignment When the proper signal is received by the cell, it then under goes division and this signals circulate the bloodstream originating from growth factors. The cell undergoes a cell cycle when the messages for dividing are received by the cell and this involves several division phases
Cancer Research Papers
Two new studies suggest that aneuploidy helps the cells survive treatments like chemotherapy and targeted therapies. New research suggests that fungi in the gut may affect how tumors respond to cancer treatments. In mice, when bacteria were eliminated with antibiotics, fungi filled the void and impaired the immune response after radiation therapy, the study found.
FDA has approved belumosudil Rezurock for the treatment of chronic graft-versus-host disease GVHD. The approval covers the use of belumosudil for people 12 years and older who have already tried at least two other therapies. In lab studies, the antibiotic novobiocin showed promise as a treatment for cancers that have become resistant to PARP inhibitors.
The drug, cancer research paper, which inhibits a protein called Cancer research paper polymerase theta, will be tested in NCI-supported clinical trials. A drug called avasopasem manganese, which has been found to protect normal tissues from radiation cancer research paper, can also make cancer cells more vulnerable to radiation treatment, a new study in mice suggests. While doctors are familiar with the short-term side effects of immune checkpoint inhibitors, less is known about potential long-term side effects.
A new study details the chronic side effects of these drugs in people who received cancer research paper as part of treatment for melanoma. Cholesterol-lowering drugs known as PCSK9 inhibitors may improve the effectiveness of cancer immune checkpoint inhibitors, according to studies in mice.
Researchers have developed a nanoparticle that trains immune cells to attack cancer. According to the NCI-funded study, cancer research paper, the nanoparticle slowed the growth of melanoma in mice and was more effective when combined with an immune checkpoint inhibitor.
Researchers are developing a new class of cancer drugs called radiopharmaceuticals, which deliver radiation therapy directly and specifically to cancer cells. This Cancer Currents story explores cancer research paper research on these emerging therapies.
FDA has recently approved two blood tests, known as liquid biopsies, that gather genetic information to help inform treatment decisions for people with cancer. This Cancer Currents story explores how the tests are used and who can get the tests.
Cancer cells with a genetic feature called microsatellite instability-high MSI-high depend on the enzyme WRN to survive, cancer research paper. A new NCI study explains why and reinforces the idea of targeting WRN as a treatment approach for MSI-high cancer.
The gene-editing tool CRISPR is changing the way scientists study cancer, and may change how cancer is treated. This in-depth blog post describes how cancer research paper revolutionary technology is being used to better understand cancer and create new treatments.
Ned Sharpless. Patients with acute graft-versus-host disease GVHD that does not respond to steroid therapy are more likely to respond to the drug ruxolitinib Jakafi than other available treatments, results from a large clinical trial show. NCI is developing the capability to produce cellular therapies, cancer research paper, like CAR T cells, to be tested in cancer clinical trials at multiple hospital sites. Few laboratories and centers have the capability to make CAR T cancer research paper, which has limited the ability to test them more broadly, cancer research paper.
In people with blood cancers, the health of their gut microbiome appears to affect the risk of dying after receiving an allogeneic hematopoietic stem cell transplant, according to an NCI-funded study conducted at four hospitals across the globe.
A novel approach to analyzing tumors may bring precision cancer medicine to more patients. A study showed the approach, which analyzes gene expression using tumor RNA, could accurately predict whether patients had responded to treatment with targeted therapy or immunotherapy, cancer research paper.
Bone loss associated with chemotherapy appears to be induced by cells that stop dividing but do not die, a recent study in mice suggests. The researchers tested drugs that could block signals from these senescent cells and reverse bone loss in mice. Some experts believe that proton therapy is safer than traditional radiation, but research has been limited. A new observational study compared the safety and effectiveness of proton therapy and traditional cancer research paper in adults with advanced cancer.
In people with cancer, the abscopal effect occurs when radiation—or another type of localized therapy—shrinks a targeted tumor but also causes untreated tumors in the body to shrink, cancer research paper. Researchers are trying to better understand this phenomenon and take advantage of it to improve cancer therapy. An experimental drug, AMGthat targets mutated forms of the KRAS protein completely shrank tumors in cancer mouse models and data from a small clinical trial show that it appears to be active against different cancer types with a KRAS mutation.
Researchers have engineered an oncolytic virus to kill cancer cells and boost the immune response against tumors. In a new study, the virus provided T cells around tumors with a hormone they need for their own cell-killing functions. FDA has cancer research paper entrectinib Rozlytrek for the treatment of children and adults with tumors bearing an NTRK gene fusion.
The approval also covers adults with non-small cell lung cancer harboring a ROS1 gene fusion, cancer research paper. A new NCI-supported study showed that altering cancer cell metabolism by feeding mice a diet very low in the nutrient methionine improved the ability of chemotherapy and radiation therapy to shrink tumors. An NCI-funded clinical trial is testing cancer research paper immunotherapy drug nivolumab Opdivo in people who have advanced cancer and an autoimmune disease, such as rheumatoid arthritis, lupus, cancer research paper, or multiple sclerosis, who are often excluded from such trials.
Researchers have identified a protein called CD24 that may be a new target for cancer immunotherapy. CAR T-cell therapy is a rapidly emerging form of cancer treatment, primarily for blood cancers like leukemia and lymphoma.
An article about research to improve CAR T-cell therapy and expand its use. Injecting cells undergoing necroptosis, cancer research paper, a form of cell death, into tumors in mice kickstarted an immune response against the tumors, researchers have found. When combined with immunotherapy, the treatment was effective at eliminating tumors in mice.
Researchers have identified proteins that may play a central role in transforming T cells from powerful destroyers to depleted bystanders that can no longer harm cancer cells, cancer research paper. The findings could lead to strategies for boosting cancer immunotherapies. Did you know that NCI supports clinical trials of new treatments for pet dogs with cancer?
Researchers have discovered a potential way cancer research paper turn on one of the most commonly silenced tumor-suppressor proteins in cancer, called PTEN.
They also found a natural compound, I3C, that in lab studies could flip the on switch. New findings from a clinical trial suggest that a single dose of radiation therapy may control painful bone metastases as effectively as multiple lower doses of radiation therapy.
The expanding use of cancer immunotherapy has revealed a variety of side effects associated with this treatment approach, cancer research paper. Researchers are now trying to better understand how and why these side effects occur and develop strategies for better managing them.
The investigational immunotherapy drug bintrafusp alfa also called Ma bifunctional fusion protein, shrank the tumors of some patients with advanced HPV-related cancers, according to results from a phase 1 clinical trial. The NCI-led study, published in Science, examined the effect of high potassium levels on T cells. Pain is a common and much-feared symptom among people with cancer and long-term survivors. As more people survive cancer for longer periods, there is a renewed interest in developing new, nonaddictive approaches for managing their chronic pain.
The study, which used population-based data, was published in JAMA Oncology. Lyndsay Harris provides an update on cancer research paper NCI-MATCH trial, including the opening of new trial treatment arms and the addition of new laboratories to perform testing on tumor samples of prospective trial participants.
Certain cancer treatments can damage the heart and the cardiovascular system, a problem known as cardiotoxicity, cancer research paper. Cardiologists and oncologists met recently to discuss strategies and future research directions for addressing these side effects. Supriya Mohile discusses the unique issues experienced by older adults with cancer and efforts to incorporate geriatric assessment into patient care, including the publication of recent ASCO clinical guidelines on geriatric cancer care.
A study cancer research paper mice may have identified a way to help overcome resistance to targeted cancer drugs known as PI3K inhibitors. The approach appears to work by reducing insulin levels in patients receiving these drugs.
A study in mice sheds light onto how some chemotherapies cause diarrhea. The findings could be the basis for developing new treatments for patients with cancer who develop gastrointestinal side effects from chemotherapy, cancer research paper. A new study has linked age with how well patients with melanoma responded to treatment with immune checkpoint inhibitors, cancer research paper.
Experiments in mice suggested that the response pattern may be due to an age-related shift in the kinds of immune cells in tumors. The NCI Experimental Therapeutics NExT program works with researchers and top scientific experts to advance promising or novel cancer research paper therapies from the earliest stages of research to human clinical trials.
As the patents on some widely used drugs to treat cancer expire in the coming years, biosimilar drugs are being developed for the treatment of patients with cancer. Are biosimilars effective and will they expand treatment options for patients?
A novel approach to immunotherapy developed by NCI researchers has led to the complete regression of breast cancer in a patient who was unresponsive to all other treatments. The findings were published in Nature Medicine. The NCI-MATCH precision medicine clinical trial has reached a milestone with the release of results from several study treatment arms. Findings from three arms were released at the ASCO annual meeting, adding to findings from one arm released in Two independent groups of researchers have fused a TGF-beta receptor to a monoclonal antibody that targets a checkpoint protein.
The result is a single hybrid molecule called a Y-trap that blocks two pathways used by tumors to evade the immune system. Initial results from a series of three small cancer research paper trials of a targeted cancer therapy called larotrectinib suggest that it may be effective in patients—children and adults—with a wide variety of cancer types. Two compounds that target components of the circadian clock killed several types of cancer cells in the lab and slowed the growth of brain tumors in mice without harming healthy cells, a cancer research paper study showed.
A small but growing number of patients with cancer are being treated with oncolytic viruses, which infect and kill tumor cells. But research now suggests that these treatments also work against cancer by spurring an immune response, cancer research paper. Using mouse models of cancer, researchers found that altering the gut microbiome could affect whether tumors responded to checkpoint inhibition.
A new study has found the commonly used chemotherapy drug cisplatin is retained in the inner ear of mice and humans for long periods. The finding may explain why many patients treated with the drug develop hearing loss and could point toward potential ways to prevent it. Joint pain caused by aromatase inhibitors in postmenopausal women with breast cancer can cause some women to stop taking the drugs. Reducing their symptoms may translate into better adherence to therapy.
Menu Contact Dictionary Search. Understanding Cancer. What Is Cancer? Cancer Statistics. Cancer Disparities. Cancer Causes and Prevention. Risk Factors. Cancer Prevention Overview. Cancer Screening Overview, cancer research paper. Screening Tests. Diagnosis and Staging. Questions to Ask about Your Diagnosis, cancer research paper.
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Jun 23, · Researchers are developing a new class of cancer drugs called radiopharmaceuticals, which deliver radiation therapy directly and specifically to cancer cells. This Cancer Currents story explores the research on these emerging therapies. FDA Approves Blood Tests That Can Help Guide Cancer Treatment. Posted: October 15, Sep 01, · Cancer Research Print ISSN: Journal of Cancer Research ISSN: American Journal of Cancer ISSN: Advertisement There were breast, colon, and lung cancer patients identified in this analysis. Overall, % of breast, 11% of colon, and % of lung cancer patients had been prescribed ADs during the 2-year period. The clinic in which cancer
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